Following the Pathway

These studies, the authors say, reveal the cellular and molecular complexity of regulatory T cells. They raises questions about the role of different types of Treg cells in health and disease.

"I am driven to understand what causes disease," says Dr. Khazaie. "We identified multiple molecularly distinct subsets of Treg cells. These subsets responded differently to changes in expression of TCF-1, and to colon cancer in mice."

Of course, he continues, to understand why things go wrong, it helps first to learn how they normally function. And things going right is Dr. Gounari's department.

"I'm interested in understanding why Treg cells are so complex and what each subset does in the normal healthy environment. To understand how things work, you have to tweak them and see what changes," says Dr. Gounari. "It is becoming clear that we can look into the complex molecular pathways and find identifiers that help us understand how normal things work."

And the search for molecular identifiers is where Dr. Kazemian comes into play.

"Complex diseases need complex tools to decipher," says Dr. Kazemian. "Over the past few years, we have created some of these tools that help us understand such complexity."

The team's findings have paved the path for normalizing immunity in cancer to improve cancer prevention and therapy. The knowledge gained is also highly relevant to the success of transplants and the control of autoimmune diseases.

"It is the job of the scientists to go beyond the standard of care, bringing basic and translational research into clinical practice," says Dr. Khazaie. "The ultimate goal is to help patients with debilitating and life-threatening diseases